Pspp windowspackage11/22/2023 ![]() ![]() In cases where the number of groups is insufficient, probability values for Fisher correction are given. Chi-square analysis was applied to determine whether there is a relationship and dependency between the variables, according to the study groups. ![]() General characteristics, disease states, AAT levels, SERPINA 1 gene expression, clinical impact and ages of the patients were expressed as mean, standard deviation, percentage, and frequency, according to the data type. If the alpha-1 antitrypsin (AAT) serum level is 3' Health institutions such as the World Health Organization (WHO), the American and European Thoracic/Respiratory Societies (ATS/ERS) suggest that all COPD patients and adults with irreversible asthma should be tested for AATD at least once in their lifetime. 5 Current evidence suggests that the Pi * ZZ genotype is often underrecognised or misdiagnosed by clinicians in individuals with AATD. The Z mutation causes the most severe plasma deficiency and occurs in more than 95% of individuals with AATD. 4 The most common variants of AATD are Z (Glu342Lys) and S (Glu264Val) mutations. It has been reported that there is a predisposition to SP development in conditions such as alpha-1 antitrypsin deficiency(AATD). Genetically effective factors in the formation of SP have been supported by various evidence. 1,2 When it occurs in individuals with underlying lung disease, it is defined as secondary spontaneous pneumothorax (SSP) and is seen in the middle-advanced age group. When SP occurs in healthy individuals, it is referred to as primary spontaneous pneumothorax (PSP) and is usually caused by small subpleural blebs bursting in young men. Spontaneous pneumothorax (SP), which is the collection of air in the pleural space without trauma, is one of the most common diseases that causes loss of work and power in emergency medicine and thoracic surgery practice. Key Words: Primary spontaneous pneumothorax, Alpha 1 antitrypsin deficiency, Genotype variants, SERPINA 1 gene. AATD is an effective factor in the development of PSP. ![]() In addition, the effect of SERPINA 1 gene on PSP development was found to be benign. Four healthy volunteers had PI M1V variant (66.7%), and two healthy volunteers had PI M4 variant (33.3%).Ĭonclusion: AAT level was found to be lower in the patient group compared to the control group. Six patients had PI M1V variant (37.5%), five patients had PI M1A variant (31.3%), four patients had PI M4 variant (25%), and one patient had an indeterminate variant (6.2%). The presence of the SERPINA 1 gene was studied in 13 (31%) patients with AATD and 7 (16.7%) healthy volunteers. Results: In this study, AAT level was statistically and significantly lower in the patient group than the control group (p = 0.018). Presence of SERPINA 1 gene was determined in all the participants and its phenotype variants. The antitrypsin (AAT) level of all participants was measured by the ELISA method. Methodology: A total of 42 patients with PSP and 42 healthy volunteers were included in the study. Place and Duration of Study: Kayseri City Training and Research Hospital, Turkey, from October 2019 to October 2020. Study Design: Cross-sectional descriptive study. Objective: To determine the association of alpha-1 antitrypsin deficiency (AATD) in patients diagnosed with primary spontaneous pneumothorax (PSP), the presence of the SERPINA 1 gene, and the phenotype in patients with low enzyme values.
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